Gaps, Rings, and Non-Axisymmetric Structures in Protoplanetary Disks - From Simulations to ALMA Observations

Recent observations by the Atacama Large Millimeter/submillimeter Array (ALMA) of disks around young stars revealed distinct asymmetries in the dust continuum emission. In this work we want to study axisymmetric and non-axisymmetric structures, evocated by the magneto-rotational instability in the outer regions of protoplanetary disks. We combine the results of state-of-the-art numerical simulations with post-processing radiative transfer (RT) to generate synthetic maps and predictions for ALMA. We performed non-ideal global 3D MHD stratified simulations of the dead-zone outer edge using the FARGO MHD code PLUTO. The stellar and disk parameters are taken from a parameterized disk model applied for fitting high-angular resolution multi-wavelength observations of circumstellar disks. The 2D temperature and density profiles are calculated consistently from a given surface density profile and Monte-Carlo radiative transfer. The 2D Ohmic resistivity profile is calculated using a dust chemistry model. The magnetic field is a vertical net flux field. The resulting dust reemission provides the basis for the simulation of observations with ALMA. The fiducial model develops a large gap followed by a jump in surface density located at the dead-zone outer edge. The jump in density and pressure is strong enough to stop the radial drift of particles. In addition, we observe the generation of vortices by the Rossby wave instability (RWI) at the jumps location close to 60 AU. The vortices are steadily generated and destroyed at a cycle of 40 local orbits. The RT results and simulated ALMA observations predict the feasibility to observe such large scale structures appearing in magnetized disks without having a planet.Comment: Language update, added comments, added citations, in press. (A&A

Synthetic route optimization of Sumepirin antiepileptic drug candidate

In this work we describe the transformation of synthetic route of the antiepileptic drug candidate Sumepirin starting from discovery stage. Initial method included six step process requiring two steps of purification using colon chromatography and has poor overall yield of target compound. The process developed is convenient, scalable, technological and meet the most of conditions of green chemistry. The overall yield was increased up to 62.5% in four steps without colon chromatography purification which allows to obtain the target compound with purity of 99.5+% which is especially important for the active ingredient

SYNTHETIC ROUTE OPTIMIZATION OF SUMEPIRIN ANTIEPILEPTIC DRUG CANDIDATE

Epilepsy is one of the most common chronic diseases of the nervous system in the world, which affects both children and adults. 30% of patients with epilepsy are pharmacoresistant. Sumepirin 1 is a novel antiepileptic drug candidate developed in the Scientific and Educational Center of Pharmaceutics of the Kazan Federal University and having pronounced antiseizure effect and improved safety profile. This compound is pyridoxine-based molecule with residue of methanesulfonic acid in the 6th position of pyridoxine ring.This work was supported by subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientificactivities (project number 0671-2020-0053

Circumstellar disks and planets. Science cases for next-generation optical/infrared long-baseline interferometers

We present a review of the interplay between the evolution of circumstellar disks and the formation of planets, both from the perspective of theoretical models and dedicated observations. Based on this, we identify and discuss fundamental questions concerning the formation and evolution of circumstellar disks and planets which can be addressed in the near future with optical and infrared long-baseline interferometers. Furthermore, the importance of complementary observations with long-baseline (sub)millimeter interferometers and high-sensitivity infrared observatories is outlined.Comment: 83 pages; Accepted for publication in "Astronomy and Astrophysics Review"; The final publication is available at http://www.springerlink.co

Midplane temperature and outer edge of the protoplanetary disk around HD 163296

Knowledge of the midplane temperature of protoplanetary disks is one of the key ingredients in theories of dust growth and planet formation. However, direct measurement of this quantity is complicated, and often depends on the fitting of complex models to data. In this paper we demonstrate a method to directly measure the midplane gas temperature from an optically thick molecular line if the disk is moderately inclined. The only model assumption that enters is that the line is very optically thick, specifically in the midplane region where we wish to measure the temperature. Freeze-out of the molecule onto dust grains could thwart this. However, in regions that are expected to be warm enough to avoid freeze-out, this method should work. We apply the method to the CO 2–1 line channel maps of the disk around HD 163296. We find that the midplane temperature between 100 and 400 au drops only mildly from 25 K down to 18 K. While we see no direct evidence of the midplane being optically thin due to strong CO depletion by freeze-out, we cannot rule it out either. The fact that the inferred temperatures are close to the expected CO freeze-out temperature could be an indication of this. Incidently, for the disk around HD 163296 we also find dynamic evidence for a rather abrupt outer edge of the disk, suggestive of outside-in photoevaporation or truncation by an unseen companion

Gaps, rings, and non-axisymmetric structures in protoplanetary disks: Emission from large grains

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